Category B - full version without watermark 720x576 (check terms and conditions at www.teledesign.de) The version with watermark is for free to embed. The skin, a delicate sensory organ, too. Receptors respond to the different external stimuli. The receptors for pressure and touch -- the so called Meissner's corpuscules are situated in the dermis. Highly sensitive temperature receptors sense hot as well as cold stimuli. It is advisable to react quickly to such stimuli. Vibrations are registered by mechanoreceptors -- they are situated in the dermis, too. The pain receptors, free nerve endings, reach up into the outer skin layer, the epidermis. For a whole century physicians, biologists and neurophysiologists were in search of the cause for itching. The phantom has been discovered! For the often intolerable itchiness of the skin separate nerve endings have been identified. Histamine is involved in the induction of the itch impulse which then travels along the spinal cord up to the brain.