chronic pain

full version without watermark 720x576 (check terms and conditions at www.teledesign.de) The embed version with watermark is free of charge. - Chronic pain is defined as pain that persists longer than the temporal course of natural healing, associated with a particular type of injury or disease process. Under persistent activation nociceptive transmission to the dorsal horn may induce a wind up phenomenon. This induces pathological changes that lower the threshold for pain signals to be transmitted. In addition it may generate nonnociceptive nerve fibers to respond to pain signals. Nonnociceptive nerve fibers may also be able to generate and transmit pain signals. In chronic pain this process is difficult to reverse or eradicate once established